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Tuesday, August 1 • 14:00 - 15:00
Generation and evaluation of complete genomes from metagenomes

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Genomes are an integral component of the biological information about an organism and, logically, the more complete the genome, the more informative it is. Shotgun sequencing of microbial communities could potentially generate complete genomes for some organisms, but this has rarely been undertaken. Here, we describe approaches that can, in some cases, generate complete genome sequences. Using ~7000 published complete bacterial isolate genomes, we benchmark cumulative GC skew as a predictor of overall genome accuracy. We use this to identify likely mis-assemblies in some reference genomes and to confirm the topology of complete genomes from metagenomes. Complete genomes for organisms without isolates will substantially advance metabolic and evolutionary analyses.

avatar for Jillian Banfield

Jillian Banfield

Ph.D., UC Berkeley Professor (Earth & Planetary Science Dpt); Lawrence Berkeley National Laboratory Earth Sciences Division staff scientist

Tuesday August 1, 2017 14:00 - 15:00
Graduate School of Management Building, room 309 Volkhovskiy Pereulok, 3, St. Petersburg, Russia