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Wednesday, August 2 • 13:30 - 14:30
Genome 10K Project at the Dobzhansky Center in St. Petersburg

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The Genome10K project was begun in 2009 by an international consortium of biologists and genome scientists determined to facilitate the whole genome sequence and analyses of 10,000 vertebrate species.  Since then the number of species selected and accomplished has risen from ~30 to over 350 species sequenced or ongoing with funding, over 1000% increase in eight years.  I shall summarize the advances and responsibilities that have occurred to date  and lay out the achievements and present challenges of reaching the goal.  I shall review  the status of known vertebrate genome projects, recommend standards for pronouncing a species genome as sequenced or completed, and provide a present and future view of the landscape of Genome 10K.

At the Theodosius Dobzhansky Center  for Genome Bioinformatics,  we have contributed  with a the comparative analyses of 12 of the 38 living species of Felidae, a remarkable example of worldwide species radiation and adaptation to various environments.  Our study included analyses of  genome sequence of : lion (Panthera leo), tiger (Panthera tigris), snow leopard (Panthera uncia), leopard (Panthera pardus), jaguar (Panthera onca), caracal (Caracal caracal), lynx (Lynx lynx), Asian leopard cat (Prionailurus bengalensis), fishing cat (Prionailurus viverrinus), puma (Puma concolor), cheetah (Acinonyx jubatus), and domestic cat (Felis catus) - coverring six lineages of the family (Panthera, Caracal, Lynx, Asian leopard cat, Puma, and Domestic cat). For each, whole-genome assembled sequence was assessed and annotated including genes, repeats, and variants and other features . A structural alignment of the genomes was performed to identify homology and rearrangements between them. Homozygosity regions were determined based on single nucleotide variants called in the sequenced specimens. Differences and similarities between the annotated genomes are interpreted in terms of the evolutionary process that took place 10.8 million years ago and initiated branching from the last common Felid ancestor.

The Genome 10K endeavor is ambitious, bold, expensive and uncertain, but together the Genome 10K Consortium of Scientists (G10KCOS) and the world genomics community are moving deliberately toward their goal of delivering to the coming generation a gift of genome empowerment for many vertebrate species. 



Wednesday August 2, 2017 13:30 - 14:30
Graduate School of Management Building, room 309 Volkhovskiy Pereulok, 3, St. Petersburg, Russia